Public Health Wales (PHW) have said that more than 1m people have now received their first vaccine dose.
On Tuesday PHW said that 1,007,391 people have now had their first vaccine dose, whilst 192,030 have had both vaccinations.
In 13 weeks the Welsh vaccination programme has provided almost 40% of people with protection against the virus.
The seven day case rate now stands at 44 cases per 100,000 population, according to latest PHW data.
The Welsh First Minister, Mark Drakeford is expected to announce on Friday the lifting of the “stay at home” rule as it will be the three week review.
Health Minister Vaughan Gething said, “To be able to say that one in four adults in Wales have now had at least their first dose of the vaccine is a truly incredible testament to the hard work of everyone involved in the rollout of this life-changing vaccine.
“We have seen an incredible level of uptake so far and my thanks go to every person who has done their bit for this national effort.
“It is crucial these high levels of uptake are maintained and I would urge everyone to take up their offer – every single dose really does count.
“Each is a step closer to opening up our society, a step closer to a brighter future and our ‘new normal’.
“We do however need to reiterate that even if you have had your jab, please keep to the social distancing and hygiene measures we’ve become accustom to over the past year – everyone’s efforts to keep this virus at bay are so vitally important.”